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pentobarbital will minimize the extent or impact of tipranavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will decrease the extent or outcome of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not suggested; strong cytochrome P450 enzyme induc